Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Experimental otitis media with effusion induced by platelet activating factor

C K Rhee1, T T Jung, S Miller

  • 1Division of Otolaryngology-Head and Neck Surgery, Loma Linda University School of Medicine, California.

The Annals of Otology, Rhinology, and Laryngology
|August 1, 1993
PubMed
Summary

Platelet activating factor (PAF) can cause otitis media with effusion (OME). PAF antagonists, like WEB 2170, effectively prevent this condition, suggesting PAF

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Modeling the impact of high thermal conductivity paper on the performance and life of power transformers.

Heliyon·2024
Same author

Occupational exposure and idiopathic pulmonary fibrosis: a multicentre case-control study in Korea.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2017
Same author

Incidence and prevalence of idiopathic interstitial pneumonia and idiopathic pulmonary fibrosis in Korea.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2016
Same author

The Medical Costs of Chronic Obstructive Pulmonary Disease in South Korea.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2016
Same author

Effect of roflumilast on airway remodelling in a murine model of chronic asthma.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2015
Same author

Risk factors for lung function impairment among the general non-smoking Korean population.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2015

Area of Science:

  • Otolaryngology
  • Immunology
  • Pharmacology

Background:

  • Otitis media with effusion (OME) is a common condition.
  • The role of specific inflammatory mediators in OME pathogenesis requires further elucidation.

Purpose of the Study:

  • To investigate the role of platelet activating factor (PAF) in inducing middle ear effusion (ME) and inflammation.
  • To evaluate the efficacy of PAF antagonists in preventing PAF-induced OME.

Main Methods:

  • Chinchilla bullae were injected with varying doses of PAF.
  • Middle ear effusion (MEE) and inflammatory markers were analyzed.
  • The effect of a PAF antagonist (WEB 2170) on PAF-induced OME was assessed.

Main Results:

Related Experiment Videos

  • PAF injection induced middle ear effusion (MEE) and inflammation in a dose-dependent manner, with peak effects at 1 and 16 micrograms.
  • MEE contained various inflammatory products, and elevated PAF levels were detected.
  • Intraperitoneal administration of WEB 2170 significantly prevented PAF-induced OME.

    • Conclusions:

    • Platelet activating factor (PAF) is a potent inducer of otitis media with effusion (OME).
    • PAF antagonists demonstrate therapeutic potential for preventing OME.
    • PAF plays a significant role in the pathological mechanisms of OME.