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Related Experiment Videos

Mucosal fine structure in experimental sinusitis

K M Westrin1, P Stierna, B Carlsöö

  • 1Department of Otorhinolaryngology, Karolinska Institute, Huddinge Hospital, Sweden.

The Annals of Otology, Rhinology, and Laryngology
|August 1, 1993
PubMed
Summary

This study shows Streptococcus pneumoniae causes self-limiting sinusitis in rabbits, leaving lasting mucosal changes. Bacteroides fragilis, however, triggers a chronic inflammatory response in the sinus lining.

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Area of Science:

  • Microbiology
  • Pathology
  • Otolaryngology

Background:

  • Sinusitis is a common condition affecting the maxillary sinuses.
  • Understanding the histologic response to different pathogens is crucial for treatment.

Purpose of the Study:

  • To compare the histologic effects of Streptococcus pneumoniae and Bacteroides fragilis on rabbit maxillary sinus mucosa over 12 weeks.

Main Methods:

  • Rabbit maxillary sinuses were inoculated with Streptococcus pneumoniae or Bacteroides fragilis.
  • Histologic changes in the sinus mucosa were analyzed over a 12-week period.

Main Results:

  • Both pathogens caused increased cylindric cell height and basal cell hyperplasia.
  • Streptococcus pneumoniae induced a self-limiting sinusitis with persisting goblet cells, fibrosis, and edema.

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  • Bacteroides fragilis resulted in a chronic inflammatory process with mononuclear cell infiltration and mucosal thickening.

    • Conclusions:

    • Pneumococcal sinusitis in rabbits is self-limiting with specific mucosal sequelae.
    • B. fragilis infection leads to a chronic inflammatory response in the sinus mucosa.