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The reversal of multidrug resistance in cancer (review)
1Department of Clinical Biochemistry, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
Anticancer Research
|July 1, 1993
Abstract:
A brief review of the "state of the art" (1992) knowledge concerning various strategies and tactics to overcome multidrug resistance is presented. Multidrug resistance remains the main obstacle to long-term successful cancer chemotherapy; its prevention or elimination is probably one of the most promising avenues in cancer research.
Insights
Multidrug resistance hinders successful cancer chemotherapy. Overcoming this challenge through various strategies is crucial for advancing cancer research and treatment.
Area of Science:
- Oncology
- Pharmacology
Background:
- Multidrug resistance (MDR) is a significant clinical challenge in cancer chemotherapy.
- MDR limits the efficacy of established chemotherapeutic agents, leading to treatment failure.
Purpose of the Study:
- To review the state-of-the-art knowledge (as of 1992) on strategies to overcome multidrug resistance.
- To highlight the importance of addressing MDR in cancer research.
Main Methods:
- Literature review of existing strategies and tactics.
- Analysis of the impact of multidrug resistance on chemotherapy outcomes.
Main Results:
- Various approaches exist to combat multidrug resistance.
- Multidrug resistance remains a primary impediment to effective long-term cancer treatment.
Conclusions:
- Preventing or eliminating multidrug resistance is a key area for promising advancements in cancer research.
- Further research into overcoming MDR is essential for improving patient survival rates.