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Vitamin B12 deficiency and nervous system disease in HIV infection
K R Robertson1, R A Stern, C D Hall
1AIDS Neurological Center, University of North Carolina, Chapel Hill 27599-7025.
Background:
Vitamin B12 deficiency may result in a number of neurological and neuropsychiatric disorders. Patients with human immunodeficiency virus type 1 (HIV-1) infection may have a high rate of vitamin B12 deficiency and nervous system disease. Vitamin B12 deficiency may contribute to neurological disease in HIV-1-infected individuals.
Objective:
To evaluate the possible contribution of vitamin B12 deficiency to neurological disease in HIV-1-infected individuals.
Main Outcome Measures:
Comparison of serum vitamin B12 levels with neurological, neuropsychological, and mood state abnormalities in 153 HIV-1-positive subjects and 57 high-risk seronegative controls. A subgroup of 67 subjects underwent additional extensive clinical neurophysiological, cerebrospinal fluid, and magnetic resonance imaging evaluations.
Results:
No statistically significant relationships were noted between vitamin B12 levels and abnormalities on any of the measures examined.
Conclusions:
This study does not indicate an important role for vitamin B12 deficiency in the neurological disease of HIV-1 infection.
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