Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

POU-domain proteins: structure and function of developmental regulators

M Wegner1, D W Drolet, M G Rosenfeld

  • 1Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla 92093-0648.

Current Opinion in Cell Biology
|June 1, 1993
PubMed
Summary

POU-domain proteins are crucial developmental regulators across species. Their conserved sequences help control cell differentiation and maintain specialized cell functions in various organs, advancing our understanding of developmental programs.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The influence of Ross 308 breeder flock age on serum Newcastle Disease Virus and Infectious Bursal Disease Virus antibody levels and their transfer to offspring.

Polish journal of veterinary sciences·2026
Same author

Improved Limit on the Effective Electron Neutrino Mass with the ECHo-1k Experiment.

Physical review letters·2026
Same author

Changes in carcase composition, gastrointestinal morphometry and leg bone dimensions in different goose genotypes after a four-year reproductive period.

British poultry science·2025
Same author

Development of an anthropomorphic phantom of the lower extremities for feasibility studies and verification of total-body irradiation.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)·2025
Same author

Ultrasound Guided Versus Conventional Closure Device Deployment Following Transfemoral Endovascular Procedures: A Systematic Review and Meta-analysis.

European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery·2025
Same author

Influence of the age of turkey layers on selected serological parameters and the transfer of maternal antibodies to chicks hatched from their eggs.

Polish journal of veterinary sciences·2025

Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • POU-domain proteins are key regulators of cellular development.
  • These proteins are conserved across diverse organisms, from worms to humans.
  • They play critical roles in cell differentiation and maintaining specialized cell phenotypes.

Purpose of the Study:

  • To explore the function of POU-domain proteins in developmental regulation.
  • To understand how POU-domain proteins control transcription.
  • To elucidate the mechanisms by which these proteins initiate specific developmental programs.

Main Methods:

  • Sequence conservation analysis of POU-domain proteins.
  • Characterization of POU-domain containing proteins.

Related Experiment Videos

  • Investigating the transcriptional regulatory roles of POU-domain proteins.

    • Main Results:

    • Identified conserved POU-domain sequences across species.
    • Characterized numerous POU-domain proteins involved in development.
    • Gained insights into how POU-domain proteins regulate transcription for developmental programs.

    Conclusions:

    • POU-domain proteins are fundamental developmental regulators.
    • Their conserved nature facilitates broad characterization and functional understanding.
    • Understanding their transcriptional mechanisms enhances knowledge of developmental initiation.