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[Ketanserin as antioxidant]

P M Filipe1, A C Fernandes, J A Saavedra

  • 1Instituto de Química Fisiológica, Faculdade de Medicina de Lisboa, Portugal.

Revista Portuguesa De Cardiologia : Orgao Oficial Da Sociedade Portuguesa De Cardiologia = Portuguese Journal of Cardiology : an Official Journal of the Portuguese Society of Cardiology
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

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Ketanserin, an antihypertensive drug, demonstrated significant antioxidant properties by inhibiting lipid peroxidation in vitro. This finding suggests a potential new therapeutic role for ketanserin beyond its cardiovascular effects.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Cardiovascular Medicine

Context:

  • Free radicals contribute to cardiovascular disease pathogenesis.
  • Existing cardiovascular drugs often possess antioxidant properties.
  • Ketanserin is a selective S2 receptor antagonist with antihypertensive and hemorheologic benefits.

Purpose:

  • To investigate the potential antioxidant capacity of ketanserin.
  • To evaluate ketanserin's ability to inhibit lipid peroxidation in vitro.
  • To determine if ketanserin affects free radical-induced damage.

Summary:

  • Ketanserin inhibited copper-dependent lipid peroxidation and hemolysis in human red blood cells.
  • The drug showed significant inhibition of lipid peroxidation in hepatic microsomes and brain homogenates when induced by copper(II) and hydrogen peroxide.

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  • Its efficacy was less pronounced against hydrogen peroxide-induced lipid peroxidation alone.

    • Impact:

    • This study reveals a previously unrecognized antioxidant effect of ketanserin.
    • The findings may suggest novel therapeutic applications for ketanserin in conditions involving oxidative stress.
    • Further research is needed to determine the clinical relevance of ketanserin's antioxidant activity.