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The c-myc oncogene in tumor progression

S J Garte1

  • 1Nelson Institute of Environmental Medicine, New York University Medical Center, NY 10016.

Critical Reviews in Oncogenesis
|January 1, 1993
PubMed
Summary

The c-myc oncogene drives tumor progression in various cancers, often correlating with poor prognosis and advanced disease stages. Its amplification is linked to tumor growth and development in both human and animal models.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Tumorigenesis involves complex, species-specific molecular pathways.
  • The c-myc oncogene is frequently implicated in malignant progression across diverse human cancers.
  • Elevated c-myc expression or amplification often correlates with poor prognosis and advanced tumor characteristics.

Purpose of the Study:

  • To review the role of the c-myc oncogene in tumor progression.
  • To highlight the association between c-myc and advanced neoplastic stages.
  • To examine c-myc's function in both human and experimental animal tumor models.

Main Methods:

  • Literature review of studies investigating c-myc's role in cancer.
  • Analysis of correlations between c-myc gene status and tumor progression markers.
  • Examination of c-myc involvement in various human tumor types and animal models.

Main Results:

  • c-myc acts as a "progressor" gene in breast, colon, lung, ovarian cancers, lymphomas, and squamous cell carcinomas.
  • c-myc amplification/expression is linked to hormone independence, invasiveness, and poor survival.
  • In rodent models, such as rat liver and skin carcinomas, c-myc amplification correlates with tumor size and age.

Conclusions:

  • The c-myc oncogene is a significant driver of tumor progression across multiple cancer types.
  • c-myc's role in progression is conserved in experimental models, aiding research.
  • Understanding c-myc's function is crucial for developing targeted cancer therapies.

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