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Updated: Aug 12, 2026
09:43
Measurement of Heme Synthesis Levels in Mammalian Cells
Published on: July 9, 2015
The regulation of human globin gene expression
F Grosveld1, N Dillon, D Higgs
1Laboratory of Gene Structure and Expression, National Institute for Medical Research, London, UK.
Bailliere'S Clinical Haematology
|March 1, 1993
Summary
The haemopoietic system aids study of developmental regulation. Research identifies key factors and sequences for human globin gene expression in red blood cells.
Area of Science:
- Developmental Biology
- Molecular Biology
- Hematopoiesis
Background:
- The haemopoietic system is a model for studying eukaryotic developmental regulation and differentiation.
- Early differentiation stages remain poorly understood, but globin gene regulation in erythroid cells is increasingly clear.
Purpose of the Study:
- To investigate the mechanisms of developmental regulation and differentiation.
- To understand the regulation of globin expression in erythroid lineage cells.
Main Methods:
- Identification of critical cis-acting sequences.
- Identification of important trans-acting factors.
- Analysis of interactions between sequences and factors.
Main Results:
- Key cis-acting sequences involved in globin gene regulation have been identified.
- Several important trans-acting factors have been identified.
- Current research focuses on the interplay of these elements.
Conclusions:
- Significant progress has been made in understanding globin gene regulation.
- Further research aims to elucidate how identified factors and sequences drive tissue-specific and developmental expression.
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