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Related Experiment Videos

Fish-oil-containing diet and platelet aggregation

W S Swails1, S J Bell, B R Bistrian

  • 1Harvard Medical School, Boston, Massachusetts.

Nutrition (Burbank, Los Angeles County, Calif.)
|May 1, 1993
PubMed
Summary

A short-term, high-dose fish oil diet did not significantly alter platelet function in hospitalized surgical patients, suggesting it may be safe for this population. This finding is important for managing critically ill patients receiving nutritional support.

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Area of Science:

  • Clinical Nutrition
  • Hematology
  • Immunomodulation

Background:

  • Fish oil diets show potential for immunomodulation in hospitalized patients.
  • A known side effect of fish oil is reduced platelet aggregability, prolonging bleeding time.
  • This effect is a concern for critically ill patients, despite potential benefits in cardiovascular disease.

Purpose of the Study:

  • To investigate the effect of a specific fish oil-rich enteral diet on platelet aggregation in surgical patients.
  • To determine if short-term administration of a high-dose fish oil diet impacts platelet function in a hospitalized setting.

Main Methods:

  • A prospective study involving 16 surgical patients.
  • Random assignment to receive either a fish oil-enriched diet (16.5g fish oil/1500ml) or standard enteral nutrition.

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  • Monitoring of platelet aggregation over one week of feeding.

    • Main Results:

    • Successful administration of the fish oil diet, providing approximately 14.2g/day.
    • No significant alteration in platelet aggregability was observed in the fish oil group.
    • Platelet function remained stable throughout the one-week study period.

    Conclusions:

    • Short-term (1 week) administration of a fish oil diet at this dose does not appear to affect platelet function in hospitalized surgical patients.
    • This suggests potential safety for using such nutritional interventions in this patient group.
    • Further research may explore longer-term effects and different patient populations.