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Gene therapy: adenovirus vectors

K F Kozarsky1, J M Wilson

  • 1University of Pennsylvania, Philadelphia.

Current Opinion in Genetics & Development
|June 1, 1993
PubMed
Summary

Recombinant adenoviruses are increasingly used in gene therapy models. Their ability to infect many cell types efficiently makes them promising for in vivo human gene therapy applications.

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Area of Science:

  • Biotechnology
  • Molecular Biology
  • Gene Therapy

Background:

  • Recombinant, replication-defective adenoviruses have gained prominence in experimental gene therapy models over the past year.
  • Adenoviruses exhibit broad cell tropism and do not require cell division for infection.

Purpose of the Study:

  • To highlight the potential of recombinant adenoviruses as a tool for in vivo gene therapy.
  • To underscore the advantages of adenovirus-based gene transfer systems.

Main Methods:

  • Utilizing recombinant, replication-defective adenoviruses.
  • Employing experimental models for gene therapy research.

Main Results:

  • Adenoviruses demonstrate efficient gene transfer across diverse cell types.
  • High titers of recombinant adenoviruses are achievable.
  • Adenovirus infection does not depend on cellular proliferation.

Conclusions:

  • Recombinant adenoviruses represent a promising system for in vivo human gene therapy.
  • The high efficiency and broad applicability of adenoviral gene transfer support their therapeutic potential.

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