[Morphologic findings in models of acute experimental pancreatitis]

Morphological changes found in two models of acute experimental pancreatitis are presented. Acute pancreatitis was induced in rats by the method of ligation of the lateral pancreatic ducts and by the method of the blind duodenal loop. After four hours the animals were sacrificed and processed for light and electron microscopic examination. Changes indicative of edematous and necrotizing pancreatitis were recorded. In the electron microscopic picture the predominant findings were disintegration of organelles of acinar cells and the appearance of numerous vacuoles and autophagosomes. The presented models of pancreatitis are considered to be suitable for further research into the pathogenesis and therapeutic intervention of acute pancreatitis in rats. (Fig. 15, Ref. 8.)