[Oral glucose tolerance test in late pregnancy women]

A total of 514 pregnant women had oral glucose tolerance test (OGTT) with 75g glucose load performed between 24 and 37 weeks of gestation. They were divided into 2 groups. Group I (n = 350) was normal pregnant controls. Group II (n = 164) was at high risk of DM group. With pooled data the results of OGTT from group I, a statistically derived criterion (based on 97.5 percentile approximated to the nearest 5) was devised. This criterion defines the lower limits of abnormal values for venous plasma glucose in Chinese pregnant women during an OGTT with a 75g glucose load as follows: fasting 5.5 mmol/L, 1 hour 10.2 mmol/L, 2 hours 8.2 mmol/L, 3 hours 6.6 mmol/L. These values are lower than those recommended for pregnant women by NDDG and WHO. It is a question whether the criterion derived from data in caucasian population are fit for the population in developing countries. Serum insulin release test were performed in 81 of 350 pregnant women in group I. The results showed that serum insulin release levels after a glucose load in late pregnancy were more active than those in the non-pregnant state. OGTT in women of group II with high risk of GDM showed to be more intolerant compared with those women in group I.