Host genes, parasites and parasitic infections

Resistance to infection of mammalian hosts by parasites is under genetic control at many different levels: between species, between races, breeds and lines of single species and between individuals. These genetic effects have been described in many host-parasite systems. Here we review the interaction between three elements: host genes, parasites and the environment in which parasitic infections develop. Already livestock industries exploit genetic variation between breeds, particularly for the control of trypanosomiasis and tick infestation in cattle. In most populations, and to many diseases, resistance is heritable and selective breeding for resistance in commercial livestock species has been successful experimentally. Attempts at utilizing genetic variation are placed in the broad context of the coevolution of host and parasite, the limited knowledge we have of the mode of action of resistance genes and our ability to use genetic information to predict resistance to parasites.