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SPECT in patients with cortical visual loss

I E Silverman1, S L Galetta, L G Gray

  • 1Department of Neurology, University of Pennsylvania, Philadelphia.

Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine
|September 1, 1993
PubMed
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Single-photon emission computed tomography (SPECT) can detect altered cerebral blood flow in cortical visual impairment. This functional imaging technique reveals abnormalities even when magnetic resonance imaging (MRI) is normal.

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Cortical visual impairment (CVI) can result from various neurological conditions.
  • Assessing cerebral blood flow changes is crucial for understanding CVI.
  • Magnetic resonance imaging (MRI) provides anatomical detail but may miss functional deficits.

Purpose of the Study:

  • To investigate changes in cerebral blood flow (CBF) in patients with CVI using SPECT.
  • To compare functional findings from SPECT with anatomical findings from MRI.
  • To evaluate the diagnostic utility of SPECT in CVI of diverse etiologies.

Main Methods:

  • Seven patients with CVI underwent single-photon emission computed tomography (SPECT) using 99mTc-hexamethylpropyleneamine oxime (HMPAO).
  • SPECT scans assessed regional cerebral blood flow (rCBF).

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  • SPECT findings were correlated with T2-weighted MRI scans.

    • Main Results:

    • SPECT revealed altered rCBF in appropriate visual pathway regions in six of seven patients, correlating with clinical visual field defects.
    • MRI scans were normal or showed smaller lesions than those detected by SPECT.
    • SPECT demonstrated functional abnormalities not evident on anatomical MRI.

    Conclusions:

    • SPECT with 99mTc-HMPAO is effective in detecting altered rCBF in CVI patients.
    • SPECT can identify functional deficits in CVI even when MRI is normal or nondiagnostic.
    • SPECT offers valuable insights into the pathophysiology of CVI across various causes.