Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Renal osteodystrophy in diabetic patients

Y Pei1, G Hercz, C Greenwood

  • 1Department of Medicine, Toronto Hospital, Ontario, Canada.

Kidney International
|July 1, 1993
PubMed
Summary

Diabetic patients on dialysis show fewer high-turnover bone diseases but increased aluminum accumulation. This suggests diabetes impacts renal osteodystrophy differently, affecting bone aluminum levels despite lower intake.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Understanding the association between pressure ulcers and sitting in adults: What does it mean for all of us?

Journal of tissue viability·2025
Same author

Modification and validation of the Bluebelle Wound Healing Questionnaire (WHQ) for assessing surgical site infection in wounds healing by secondary intention.

Journal of tissue viability·2025
Same author

The development of international wound debridement best practice recommendations: Consensus between nurses specialized in Wound, Ostomy and Continence Canada and the society of tissue viability.

Journal of tissue viability·2024
Same author

Psychological impact of the quarantine during the COVID-19 pandemic on the general European adult population: a systematic review of the evidence.

Epidemiology and psychiatric sciences·2022
Same author

A proof-of-concept study applying machine learning methods to putative risk factors for eating disorders: results from the multi-centre European project on healthy eating.

Psychological medicine·2021
Same author

The Identification of Low-risk Gambling Limits for Specific Gambling Activities.

Journal of gambling studies·2021

Area of Science:

  • Nephrology
  • Endocrinology
  • Bone Metabolism

Background:

  • Renal osteodystrophy is a common complication in patients with chronic kidney disease.
  • Diabetes mellitus is a prevalent comorbidity in dialysis patients, potentially influencing bone disease progression.

Purpose of the Study:

  • To investigate the specific effects of diabetes mellitus on the characteristics of renal osteodystrophy in dialysis patients.
  • To compare bone disease parameters between diabetic and non-diabetic individuals undergoing dialysis.

Main Methods:

  • Prospective study of 256 dialysis patients (25% diabetic) across three Toronto centers.
  • Data collection included clinical, laboratory parameters, deferoxamine testing, intact parathyroid hormone (PTH) levels, and iliac crest bone biopsy.
  • Comparison of bone disease prevalence and aluminum bone disease between diabetic and non-diabetic cohorts.

Related Experiment Videos

Main Results:

  • Diabetic patients had shorter dialysis duration and lower PTH levels.
  • High-turnover bone disorders were less common in diabetics, while aplastic and mild disorders were more frequent.
  • Despite lower cumulative aluminum gel intake, diabetic patients exhibited a higher rate of aluminum accumulation on bone surfaces.

Conclusions:

  • Diabetes mellitus alters the pattern of renal osteodystrophy, characterized by a lower prevalence of high-turnover bone disease.
  • Diabetic dialysis patients demonstrate an increased propensity for aluminum accumulation in bone, irrespective of intake.
  • These findings highlight unique pathophysiological pathways of bone disease in diabetic versus non-diabetic dialysis patients.