Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pulmonary complications after bone marrow transplantation]

M Giacchino1, A Busca, R Miniero

  • 1Istituto Discipline Pediatriche, Clinica Pediatrica II, Torino.

Minerva Pediatrica
|April 1, 1993
PubMed
Summary

Bone marrow transplantation (BMT) patients face significant pulmonary risks, including bacterial, fungal, and viral pneumonitis. Early diagnosis and management are crucial for improving outcomes in these vulnerable individuals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of allogeneic stem cell transplantation on thyroid function.

Journal of endocrinological investigation·2023
Same author

Haploidentical HSCT with post transplantation cyclophosphamide versus unrelated donor HSCT in pediatric patients affected by acute leukemia.

Bone marrow transplantation·2020
Same author

Recommendations for the reopening and activity resumption of the neurogastroenterology units in the face of the COVID-19 pandemic. Position of the Sociedad Latinoamericana de Neurogastroenterología.

Revista de gastroenterologia de Mexico (English)·2020
Same author

[Facial emotion recognition in children with attention-deficit/hyperactivity disorder].

Revista de neurologia·2020
Same author

Fungal infections of the central nervous system and paranasal sinuses in onco-haematologic patients. Epidemiological study reporting the diagnostic-therapeutic approach and outcome in 89 cases.

Mycoses·2018
Same author

'Real-life' report on the management of chronic GvHD in the Gruppo Italiano Trapianto Midollo Osseo (GITMO).

Bone marrow transplantation·2017

Area of Science:

  • Hematology
  • Oncology
  • Infectious Diseases

Context:

  • Pulmonary complications are frequent in bone marrow transplantation (BMT) recipients, affecting 10-50% of patients.
  • Bacterial pneumonia is common within 6 months post-BMT, linked to neutropenia and graft-versus-host disease (GVHD).
  • Fungal infections (Candida, Aspergillus) have high mortality (80%) and are associated with prolonged neutropenia and immunosuppression.

Purpose:

  • To review the spectrum of pulmonary complications following BMT.
  • To identify key risk factors and pathogens associated with post-BMT lung injury.
  • To emphasize the need for prompt diagnosis and management of pulmonary issues.

Summary:

  • Interstitial pneumonitis occurs in 10-40% of BMT patients, often caused by herpes viruses like cytomegalovirus (CMV).

Related Experiment Videos

  • In up to 60% of cases, the causative agent remains unidentified, potentially due to drug or radiation toxicity.
  • GVHD and its treatments increase susceptibility to lung infections, with GVHD possibly directly affecting lung epithelium.

    • Impact:

    • Improved understanding of pulmonary toxicity post-BMT can guide preventative strategies.
    • Diagnostic procedures like bronchoalveolar lavage are essential for targeted treatment.
    • Reduced incidence of interstitial pneumonitis has been achieved through radiation techniques like lung shielding and dose fractionation.