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Updated: Aug 12, 2026

Intravital Microscopy of Monocyte Homing and Tumor-Related Angiogenesis in a Murine Model of Peripheral Arterial Disease
Published on: August 26, 2017
[The natural history of peripheral arteriopathy]
Insights
Peripheral arteriopathy of the lower limbs, a form of atherosclerosis, has a significant impact on cardiovascular health. While local progression is manageable, comorbid arteriosclerotic disease in other vascular areas presents the primary challenge.
Area of Science:
- Vascular Medicine
- Cardiovascular Epidemiology
Context:
- Peripheral arteriopathy of the lower limbs is a manifestation of systemic atherosclerosis.
- Understanding its natural history is crucial for managing cardiovascular risk.
Purpose:
- To review the literature on the prevalence, incidence, and temporal course of peripheral arteriopathy.
- To examine the associated cardiovascular morbidity and mortality.
Summary:
- Literature review indicates local worsening in 25% of cases and amputation in up to 5%.
- Cardiovascular and cerebrovascular complications are significant concerns.
- Discrepancies in literature findings are attributed to varied methodologies.
Impact:
- Highlights the critical importance of managing systemic arteriosclerotic disease in patients with peripheral arteriopathy.
- Informs clinical practice regarding risk stratification and comprehensive patient care.
Abstract:
An the content of atherosclerosis, knowledge of the natural history of peripheral arteriopathy of the lower limbs is of fundamental importance. The authors review the literature involved; in particular they examine the prevalence of peripheral arteriopathy, its incidence and multimodal course in time. It is very interesting to state the cardiovascular morbility and mortality owing to pathology of the coronary district as well as the cerebral one during the course of peripheral arteriopathy. The literature conclusions are not univocal; this matter is principally due to different approach methodologies. As far as arteriopathy of inferior limbs is concerned, the literature shows that we can have a worsening in the local picture for 25% of the cases involved, considering the worst hypothesis; amputation involves at the most 5% of the cases. The real problem in these patients is the presence of arteriosclerotic disease involving other different vascular districts.
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