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Identification of a structural glycoprotein of an RNA virus as a ribonuclease
R Schneider1, G Unger, R Stark
1Department of Biochemistry, Faculty of Natural Sciences, University of Innsbruck, Austria.
Science (New York, N.Y.)
|August 27, 1993
Abstract:
One of the three structural glycoproteins of classical swine fever virus (CSFV) is E0, a disulfide-bonded homodimer that induces virus-neutralizing antibodies and occurs in a virion-bound as well as a secreted form. E0 was shown to be similar to a family of fungal and plant ribonucleases. Purified E0 from CSFV-infected cells was a potent ribonuclease specific for uridine and inhibitable by zinc ions.