Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Collection of familial data in pharmacogenetics. Methodological problems]

N Poisson1, Y Bechtel, P De La Selle

  • 1Unité de Recherches d'Epidémiologie Génétique (INSERM U 155), Château de Longchamp, Paris.

Therapie
|January 1, 1993
PubMed
Summary

Recruiting families for pharmacogenetic studies presents challenges, including eligibility criteria and participant recruitment. General practitioners are more effective for recruiting families with specific structures for epidemiological research.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synthesis and evaluation of hybrid molecules targeting the vinca domain of tubulin.

Organic & biomolecular chemistry·2015
Same author

The regulatory role of the tetrapeptide AcSDKP in skin and hair physiology and the prevention of ageing effects in these tissues--a potential cosmetic role.

International journal of cosmetic science·2013
Same author

Estimation of the incidence of pleural mesothelioma according to death certificates in France.

American journal of industrial medicine·2002
Same author

Regulation of the acetoin catabolic pathway is controlled by sigma L in Bacillus subtilis.

Journal of bacteriology·2001
Same author

[Evaluation of occupational exposures in lung cancer].

Revue des maladies respiratoires·2000
Same author

Epidemiological evidence on the carcinogenicity of silica: factors in scientific judgement.

The Annals of occupational hygiene·2000

Area of Science:

  • Pharmacogenetics
  • Genetics
  • Epidemiology

Context:

  • Family-based pharmacogenetic studies require specific recruitment strategies.
  • Polycyclic aromatic hydrocarbon (PAH) exposure influences cytochrome P4501A inducibility.
  • Data collection from nuclear families, including smokers, poses unique challenges.

Purpose:

  • To identify and analyze problems encountered during family data collection for a pharmacogenetic study.
  • To investigate the genetic polymorphism of cytochrome P4501A inducibility by PAHs.
  • To evaluate recruitment methods and methodological issues in family-based genetic research.

Summary:

  • The study involved 76 smoker nuclear families (315 volunteers) using caffeine tests, blood samples, and questionnaires.

Related Experiment Videos

  • Key challenges included recruiting families with specific compositions (two smoker parents and two smoker children) and varying recruitment source effectiveness.
  • Methodological issues involved test acceptability, particularly in females, and laboratory coordination.

    • Impact:

    • General practitioners are highlighted as valuable for recruiting specific family structures in epidemiological studies.
    • Findings suggest improving test acceptability, potentially by altering caffeine form, and emphasize the need for robust coordination in family-based genetic research.
    • This research provides insights into optimizing data collection for future pharmacogenetic and epidemiological studies.