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Bednar tumor pattern in recurring giant cell fibroblastoma
J P De Chadarévian1, D Coppola, D F Billmire
1Department of Pathology, St. Christopher's Hospital for Children, Philadelphia, PA 19134-1095.
American Journal of Clinical Pathology
|August 1, 1993
Summary
Giant cell fibroblastoma (GCF) and Bednar tumor (BT) are rare soft tissue neoplasms. This case documents a direct link between GCF and BT, suggesting a shared origin with dermatofibrosarcoma protuberans.
Area of Science:
- Oncology
- Dermatopathology
- Soft Tissue Neoplasms
Background:
- Giant cell fibroblastoma (GCF) and Bednar tumor (BT) are rare soft tissue neoplasms.
- Previously, studies suggested a relationship between GCF and dermatofibrosarcoma protuberans (DFSP), and separately between BT and DFSP.
- However, a direct link between GCF and BT has not been established.
Observation:
- A case of a young girl with a vulvar GCF initially resected at one year of age.
- The patient experienced a recurrence 1.5 years later.
- The recurrent tumor presented as a mixed Bednar tumor-Giant cell fibroblastoma.
Findings:
- This case provides evidence for a direct relationship between GCF and BT.
- The findings support the hypothesis that both GCF and BT may share a common origin or pathway with DFSP.
- This is the first documented instance of a direct link between GCF and BT.
Implications:
- Reclassifying GCF and BT may be necessary, considering their potential relationship to DFSP.
- Understanding the shared etiology of these soft tissue neoplasms can aid in diagnosis and treatment.
- Further research into the molecular mechanisms underlying GCF, BT, and DFSP is warranted.