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Differences in acetylcholine receptor-antibody interactions between extraocular and extremity muscle fibers
1National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.
Annals of the New York Academy of Sciences
|June 21, 1993
Abstract:
There are two types of motor nerve innervation patterns and AChR distributions in human EOM: single and multiple. The latter is further divided into two subgroups that are restricted to EOM and are not found in limb muscles. Epitopes that are unique to EOM end-plates exist. Some OMG patients have antibodies that are specifically targeted to those epitopes. These antibodies are functionally active and can cause AChR loss in EOM end-plates. In addition to AChRs, specific components constructing the microenvironment surrounding them may also be involved in the susceptibility of EOM in myasthenia gravis.