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[Sublingual specific immunotherapy for rhinoconjunctivitis caused by grass pollens]
A Sabbah1, J Lesellin, S Hassoun
1Laboratoire d'Immuno-Allergologie, C.H.U.F., Angers.
Allergie Et Immunologie
|June 1, 1993
Summary
Sublingual immunotherapy using grass pollen extract significantly reduced allergic rhinitis and conjunctivitis symptoms in patients. This grass pollen immunotherapy was found to be safe, effective, and economical for treating seasonal allergies.
Area of Science:
- Allergy and Immunology
- Otolaryngology
Background:
- Rhino-conjunctivitis is a common allergic condition triggered by grass pollen.
- Current treatments often manage symptoms but do not address the underlying immune response.
Purpose of the Study:
- To evaluate the efficacy and safety of sublingual immunotherapy (SLIT) with a standardized 5-grass pollen extract.
- To assess the impact of SLIT on clinical symptoms and medication use in patients with grass pollen-induced rhino-conjunctivitis.
Main Methods:
- A double-blind, placebo-controlled study involving 58 patients with grass pollen rhino-conjunctivitis.
- Patients received either 5-grass pollen allergen extract or placebo sublingually for 5 months.
- Clinical symptoms and the use of authorized medications were assessed.
Main Results:
- Active treatment group showed significantly reduced rhinitis (sneezing, rhinorrhea) and conjunctivitis (reddening, tearing) symptoms compared to placebo (P = 0.05 to P = 0.01).
- Significantly lower consumption of nasal cromoglycate, betamethasone, and dexchlorpheniramine was observed in the desensitized group (p = 0.01).
- Adverse effects were negligible.
Conclusions:
- Sublingual immunotherapy with grass pollen extract is an efficacious treatment for rhino-conjunctivitis.
- This method of immunotherapy is easy to administer, cost-effective, and safe for patients sensitive to grass pollen allergens.