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Bienzyme strip-type glucose sensor
1Institute of Biochemistry, Lithuanian Academy of Sciences, Vilnius-MTP.
Biosensors & Bioelectronics
|January 1, 1993
Summary
This study presents a novel screen-printed glucose biosensor for accurate blood glucose monitoring. The developed sensor offers a rapid and stable response, suitable for clinical applications.
Area of Science:
- Biomedical Engineering
- Electrochemistry
- Biosensors
Background:
- Accurate glucose monitoring is crucial for diabetes management.
- Existing glucose sensors face challenges in stability and response time.
Purpose of the Study:
- To develop and characterize a novel strip-type glucose biosensor using screen-printing technology.
- To evaluate the performance of the biosensor for whole blood glucose determination.
Main Methods:
- Screen-printing technology for biosensor fabrication.
- Incorporation of glucose oxidase, peroxidase, and ferrocyanide mediator into graphite-hydroxyethyl cellulose matrices.
- Electrochemical detection at 0.0 V vs Ag/AgCl electrode.
Main Results:
- The biosensor exhibited a linear calibration up to 25 mM glucose.
- A rapid response time of 50-60 seconds was achieved.
- Stable sensor performance was observed across a pH range of 7.0-8.5 and was insensitive to ascorbic acid.
Conclusions:
- The developed screen-printed glucose biosensor is a promising tool for rapid and reliable glucose determination in whole blood.
- The sensor's stability and insensitivity to interfering substances enhance its clinical applicability.