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Total glossectomy with laryngeal preservation

R Tiwari1, A B Karim, A J Greven

  • 1Department of Otolaryngology-Head and Neck Surgery, Free University Hospital, Amsterdam, The Netherlands.

Archives of Otolaryngology--Head & Neck Surgery
|September 1, 1993
PubMed
Summary

This study shows that combining surgery with radiotherapy for advanced tongue and tongue base cancers can preserve speech and swallowing functions. Properly selected patients achieved good local and regional control, maintaining a good quality of life.

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Area of Science:

  • Oncology
  • Surgical Oncology
  • Head and Neck Cancer

Background:

  • Advanced squamous cell carcinomas of the tongue and tongue base (T3-T4) present significant management challenges.
  • Laryngeal preservation is a key consideration in optimizing functional outcomes for these patients.

Purpose of the Study:

  • To evaluate the efficacy of a combined surgical and postoperative radiotherapy approach for managing large tongue and tongue base squamous cell carcinomas.
  • To assess the feasibility of laryngeal preservation in selected patients with advanced oral cavity cancers.

Main Methods:

  • A cohort of 21 patients with T3-T4 squamous cell carcinomas of the tongue/tongue base underwent planned combined therapy.
  • Surgical management involved tumor resection with options for mandibular involvement and reconstruction using myocutaneous or muscle flaps.

Related Experiment Videos

  • All patients underwent laryngeal suspension and received postoperative megavolt radiotherapy (66 Gy in 6 weeks).

    • Main Results:

    • All patients achieved resumption of swallowing and speech.
    • Patients experienced minimal external deformity and were able to return to their families.
    • The combined approach demonstrated successful local and regional tumor control.

    Conclusions:

    • Total glossectomy with laryngeal preservation is a viable treatment option for carefully selected patients with advanced tongue and tongue base cancers.
    • This therapeutic strategy effectively achieves local and regional disease control while preserving a good quality of life.