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Inner ear damage due to lipoid nephrosis

H Yamane1, Y Nakai

  • 1Department of Otolaryngology, Osaka City University Medical School, Japan.

European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
|January 1, 1993
PubMed
Summary

Lipoid nephrosis damages the inner ear, specifically the stria vascularis and vestibular hair cells in rats. Auditory function remained normal, but structural changes indicate susceptibility to this kidney disease.

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Area of Science:

  • Oto-nephrology
  • Cell biology
  • Pathology

Background:

  • Lipoid nephrosis, a kidney disease, can affect other organs.
  • The inner ear's susceptibility to systemic diseases like lipoid nephrosis is not well understood.

Purpose of the Study:

  • To investigate inner ear pathology in rats with puromycin aminonucleoside-induced lipoid nephrosis.
  • To identify specific structural changes in the cochlea and vestibular system.

Main Methods:

  • Induction of lipoid nephrosis in adult rats using puromycin aminonucleoside.
  • Evaluation of inner ear structures, including the stria vascularis, organ of Corti, and vestibular system.
  • Assessment of auditory brain-stem responses.

Main Results:

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  • No abnormalities were found in auditory brain-stem responses.
  • Significant swelling of intermediate cells in the stria vascularis was observed, compressing marginal cells.
  • Marginal cells showed vacuolization and increased lysosomes, protruding into the endolymphatic space.
  • Type I hair cells in the semicircular canals exhibited vacuolization.
  • The organ of Corti and vestibular maculae remained largely unaffected.

Conclusions:

  • Lipoid nephrosis induces significant pathological changes in the rat inner ear, particularly the stria vascularis and vestibular hair cells.
  • These findings suggest the inner ear is vulnerable to damage in lipoid nephrosis.
  • Further research is needed to understand the mechanisms and clinical implications of inner ear involvement in nephrotic syndromes.