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Declining bone loss rate variability with increasing follow-up time

Y F He1, J W Davis, P D Ross

  • 1Hawaii Osteoporosis Center, Honolulu 96814.

Bone and Mineral
|May 1, 1993
PubMed
Summary
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Bone loss variability in post-menopausal women is significant, even after accounting for measurement errors. Extreme bone loss rates observed over short periods are often not sustained long-term.

Area of Science:

  • Bone Densitometry
  • Gerontology
  • Epidemiology

Background:

  • Bone loss rates are presumed to vary significantly among post-menopausal women.
  • This perceived variability may be exaggerated by measurement errors in bone mass instrumentation.
  • Instrumentation precision (1-2% error) is comparable to annual bone loss rates (1-2%).

Purpose of the Study:

  • To estimate the true variability in bone loss rates by adjusting for measurement errors.
  • To examine the impact of follow-up duration on observed and adjusted bone loss variability.
  • To assess the implications for sample size calculations in longitudinal bone loss studies.

Main Methods:

  • Developed an equation to estimate true bone loss variability, adjusting for instrument errors.

Related Experiment Videos

  • Analyzed a cohort of post-menopausal Japanese-American women in Hawaii.
  • Measured bone mass at the calcaneus, distal radius, and proximal radius sites.

    • Main Results:

    • Measurement errors did not significantly inflate the estimated bone loss variability.
    • Considerable variability in bone loss rates persisted even after adjustment for measurement errors.
    • Both observed and adjusted bone loss rates exhibited smaller standard deviations over longer follow-up intervals compared to shorter ones.

    Conclusions:

    • Substantial individual differences in bone loss rates exist among post-menopausal women, independent of measurement error.
    • Extreme bone loss rates are less likely to be sustained over extended periods.
    • Follow-up duration and instrument precision are critical factors when comparing bone loss rates between populations.