Is premenstrual syndrome an endocrine disorder?
J H Schagen van Leeuwen1, E R te Velde, H P Koppeschaar
1Department of Obstetrics and Gynaecology, St. Antonius Ziekenhuis Nieuwegein, The Netherlands.
Journal of Psychosomatic Obstetrics and Gynaecology
|June 1, 1993
Summary
The exact cause of premenstrual syndrome (PMS) remains unknown, despite common belief in hormonal links. Evidence suggests a multidisciplinary approach is needed, not just focusing on ovarian hormones.
Area of Science:
- Reproductive endocrinology
- Psychosocial health
- Epidemiology
Background:
- Premenstrual phenomena are often attributed to cyclic ovarian hormone fluctuations.
- This assumption leads to hormonal treatments for premenstrual syndrome (PMS), despite an unknown endocrine mechanism.
- Psychosocial factors are frequently considered secondary contributors to PMS.
Purpose of the Study:
- To critically evaluate the evidence supporting an endocrine factor as the primary cause of premenstrual syndrome (PMS).
- To explore the etiological role of hormonal fluctuations versus other factors in PMS pathogenesis.
Main Methods:
- A comprehensive review of existing literature was conducted.
- An epidemiological approach was employed to assess the strength of evidence.
- The study examined the scientific basis for attributing PMS solely to endocrine mechanisms.
Main Results:
- The evidence for a purely endocrine cause of premenstrual syndrome (PMS) is not as strong as commonly believed.
- The search for a single endocrine 'Holy Grail' mechanism may be misguided.
- Cyclical ovarian activity is only one of several etiological factors in PMS.
Conclusions:
- Understanding human behavior and premenstrual syndrome (PMS) requires a broader perspective beyond hormonal influences.
- A multidisciplinary approach, integrating various etiological factors, is essential for unraveling the pathogenesis of premenstrual syndrome (PMS).
- Future research should consider the complex interplay of biological, psychological, and social factors in PMS.
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