Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A new technique for evaluating nitrogen washout efficiency

J L Mauderly

    American Journal of Veterinary Research
    |January 1, 1977
    PubMed
    Summary

    A new metric, the nitrogen dilution constant (NDC), quantifies lung nitrogen washout efficiency. This NDC is a reliable indicator of lung function changes with age and disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: II. Comparison of responses to diesel and gasoline engine exhausts, hardwood smoke and simulated downwind coal emissions.

    Inhalation toxicology·2014
    Same author

    The National Environmental Respiratory Center (NERC) experiment in multi-pollutant air quality health research: IV. Vascular effects of repeated inhalation exposure to a mixture of five inorganic gases.

    Inhalation toxicology·2014
    Same author

    Health effects of subchronic inhalation exposure to gasoline engine exhaust.

    Inhalation toxicology·2008
    Same author

    Health effects of subchronic exposure to environmental levels of hardwood smoke.

    Inhalation toxicology·2006
    Same author

    Health effects of subchronic exposure to environmental levels of diesel exhaust.

    Inhalation toxicology·2004
    Same author

    Effects of subchronic inhalation exposure of rats to emissions from a diesel engine burning soybean oil-derived biodiesel fuel.

    Inhalation toxicology·2002

    Area of Science:

    • Pulmonary Physiology
    • Respiratory Medicine

    Background:

    • Lung nitrogen washout curves are used to assess respiratory system efficiency.
    • Existing methods for analyzing these curves have limitations in sensitivity and consistency.

    Purpose of the Study:

    • To introduce and validate a new index, the nitrogen dilution constant (NDC), for quantifying lung nitrogen washout.
    • To evaluate the NDC's sensitivity in detecting age-related changes and its utility in interstitial lung disease.

    Main Methods:

    • Nitrogen washout curves were generated from open-circuit N2 washouts in human and canine subjects.
    • Curves were analyzed graphically, focusing on the second component's slope (B 1/2).
    • The nitrogen dilution constant (NDC) was defined as B 1/2 normalized by the ratio of functional residual capacity (FRC) to tidal volume (Vt).

    Main Results:

    • The NDC was found to be relatively constant within individuals, irrespective of FRC or Vt.
    • The NDC demonstrated less variation among subjects compared to other washout efficiency indices.
    • The NDC proved more sensitive than other indices in detecting age-related declines in lung washout efficiency.

    Conclusions:

    • The nitrogen dilution constant (NDC) offers a robust and sensitive measure of lung nitrogen washout efficiency.
    • NDC is a valuable tool for assessing age-related changes in lung function.
    • NDC shows promise for evaluating patients with interstitial lung disease.

    Related Experiment Videos