Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathophysiology of perinatal asphyxia

C E Williams1, C Mallard, W Tan

  • 1Research Centre for Developmental Medicine and Biology, University of Auckland, New Zealand.

Clinics in Perinatology
|June 1, 1993
PubMed
Summary

Early intervention after severe asphyxia can rescue cells, but human trial extrapolation requires careful consideration of long-term outcomes and vulnerable infants. Continuous monitoring aids in assessing injury severity and guiding treatment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the effects of hypoxic storage on platelet function and health using a novel storage system.

Transfusion·2024
Same author

Scholarship in anesthesiology: the role of critical appraisal, literature review, quality improvement, journal club, and presentation skills.

International journal of obstetric anesthesia·2023
Same author

"Double-dose desogestrel: Is it effective in adolescent menstrual dysfunction?" - Response to Güven et al.

Journal of pediatric and adolescent gynecology·2022
Same author

Double-Dose Desogestrel: Is it Effective in Adolescent Menstrual Dysfunction?

Journal of pediatric and adolescent gynecology·2021
Same author

Ring and peg electrodes for minimally-Invasive and long-term sub-scalp EEG recordings.

Epilepsy research·2017
Same author

Skin grafts from genetically modified α-1,3-galactosyltransferase knockout miniature swine: A functional equivalent to allografts.

Burns : journal of the International Society for Burn Injuries·2017

Area of Science:

  • Neuroscience
  • Neonatal Medicine
  • Cellular Biology

Background:

  • Severe asphyxia can trigger cellular recovery processes, offering a therapeutic window for intervention.
  • Extrapolation from animal models to human trials requires careful consideration of specific outcomes.
  • Identifying infants most likely to benefit from treatment is critical for effective clinical application.

Purpose of the Study:

  • To explore the potential for therapeutic intervention following severe asphyxia.
  • To highlight key principles for translating findings from animal studies to human neonates.
  • To emphasize the importance of timing and injury phase in therapeutic strategies.

Main Methods:

  • Review of cellular recovery mechanisms post-asphyxia.

Related Experiment Videos

  • Discussion of critical factors for human trial design.
  • Exploration of advanced neuromonitoring techniques.

    • Main Results:

    • Cellular recovery is possible post-asphyxia, with a therapeutic window for intervention.
    • Long-term outcomes and effects on growth-restricted infants require further investigation.
    • Continuous monitoring techniques show promise in assessing injury severity and phase.

    Conclusions:

    • Therapeutic intervention following severe asphyxia holds potential for cell rescue.
    • Careful consideration of human trial principles, including long-term effects and specific populations, is essential.
    • Advanced neuromonitoring technologies are crucial for real-time assessment and guiding timely, effective interventions.