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Intestinal permeability to [51Cr]EDTA in infectious diarrhea
M J Zuckerman1, M T Watts, B D Bhatt
1Department of Medicine, Texas Tech University Health Sciences Center, El Paso 79905.
Digestive Diseases and Sciences
|September 1, 1993
Summary
The chromium-51 ethylenediaminetetraacetic acid ([51Cr]EDTA) test reveals increased intestinal permeability in patients with infectious diarrhea. This finding highlights infections as a key cause of compromised gut barrier function.
Area of Science:
- Gastroenterology
- Clinical Medicine
- Diagnostic Testing
Background:
- Intestinal permeability is a crucial indicator of gut health.
- Assessing changes in gut barrier function is vital for diagnosing gastrointestinal disorders.
Purpose of the Study:
- To evaluate intestinal permeability using the [51Cr]EDTA test in patients with infectious diarrhea.
- To compare intestinal permeability between patients with infectious diarrhea and healthy controls.
Main Methods:
- Oral administration of approximately 100 microCi of [51Cr]EDTA after an overnight fast.
- Collection of urine for 24 hours to measure [51Cr]EDTA excretion.
- Analysis of 87 subjects, including 63 controls and 24 patients with infectious diarrhea.
Main Results:
- Controls exhibited low intestinal permeability with a mean 24-hr urinary [51Cr]EDTA excretion of 1.6%.
- Patients with infectious diarrhea showed significantly increased [51Cr]EDTA excretion (mean 6.1%, P < 0.0001).
- Elevated intestinal permeability was observed in 75% of patients with infectious diarrhea.
Conclusions:
- Infectious diarrhea is associated with significantly increased intestinal permeability.
- The [51Cr]EDTA test is a valuable tool for assessing gut barrier function in infectious enteritis.
- Intestinal infections should be considered a potential cause of elevated intestinal permeability.