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Related Experiment Videos

Intestinal epithelial function: the case for immunophysiological regulation. Implications for disease (2)

D M McKay1, M H Perdue

  • 1Department of Pathology, Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada.

Digestive Diseases and Sciences
|September 1, 1993
PubMed
Summary
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Immune cells modulate epithelial function, aiding antigen removal but potentially causing disease with chronic stimulation. Understanding this immune regulation offers new therapeutic targets for intestinal inflammation.

Area of Science:

  • Immunology
  • Gastroenterology
  • Epithelial Biology

Background:

  • Epithelial function, including ion secretion and permeability, is modulated by immune responses.
  • Animal models of anaphylaxis demonstrate immune cell involvement in epithelial physiology.
  • Part one of this review detailed immune cells and mediators influencing epithelial function.

Purpose of the Study:

  • To review the significance of immune system activation on epithelial function.
  • To explore how immune stimulation can be beneficial or detrimental to the host.
  • To highlight immune regulation relevant to human intestinal inflammatory and secretory diseases.

Main Methods:

  • Review of existing literature on immunomodulation of epithelial function.
  • Analysis of animal models of anaphylactic reactions.

Related Experiment Videos

  • Discussion of immune mediators and cytokines affecting epithelial physiology.

    • Main Results:

    • Antigenic activation of the mucosal immune system can alter epithelial function to mediate antigen loss.
    • Chronic or inappropriate immune stimulation can lead to pathophysiological reactions and disease.
    • Immune regulation of epithelial function is directly applicable to understanding human intestinal diseases.

    Conclusions:

    • Immune responses play a critical role in regulating epithelial function.
    • Dysregulated immune responses contribute to intestinal inflammatory and secretory diseases.
    • Targeting immune events offers potential therapeutic strategies for intestinal inflammation.