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Immunodeficiency Diseases

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...

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Updated: Jun 23, 2026

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

Immune neutropenia

A L Lightsey, R M Chapman, R McMillan

Annals of Internal Medicine

|January 1, 1977

Summary

This summary is machine-generated.

Severe neutropenia in a hyperthyroid patient was linked to an immune cause. Researchers identified specific neutrophil-binding IgG in the patient's serum, confirming an autoimmune mechanism for the low neutrophil count.

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The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood

The Isolation and Characterization of Low- and Normal- Density Neutrophils from Whole Blood

Published on: February 7, 2025

Area of Science:

Immunology
Hematology

Background:

Autoimmune disorders can manifest with cytopenias, including neutropenia.
Hyperthyroidism is occasionally associated with hematological abnormalities.

Observation:

A patient presented with hyperthyroidism and severe neutropenia, with a clinical history suggestive of an immune etiology.
The presence of neutrophil-binding immunoglobulin G (IgG) was detected in the patient's serum using the Fab-anti Fab assay.

Findings:

The identified antineutrophil factor demonstrated specific binding to homologous and autologous neutrophils.
This factor could be adsorbed by target neutrophils, indicating specific antibody-mediated interaction.
Quantification revealed 175,000 IgG molecules per neutrophil binding site and a serum concentration of 1.3 µg/mL.
Serum IgG levels were sufficient to saturate 1.2 times the total blood neutrophil pool during periods of marked neutropenia.

Implications:

This study provides evidence for an autoimmune basis of neutropenia in a patient with hyperthyroidism.
The findings highlight the utility of the Fab-anti Fab assay in diagnosing immune-mediated neutropenia.
Understanding the specific IgG binding characteristics offers insights into the pathogenesis of autoimmune neutropenia.