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[Gestational age and fetal lung maturity]

J Francoual1, C Benattar, P Fournet

  • 1Laboratoire de Blochimie, Hôpital Antoine-Béclère, Clamart.

Journal De Gynecologie, Obstetrique Et Biologie De La Reproduction
|January 1, 1993
PubMed
Summary

The FLM-TDX Abbott test and phosphatidylglycerol (PG) analysis assess fetal lung maturity. FLM-TDX Abbott is a reliable indicator, especially when PG is present, and doesn

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Area of Science:

  • Obstetrics and Gynecology
  • Neonatology
  • Biochemistry

Context:

  • High-risk pregnancies, including those with diabetes, premature rupture of membranes, hypertension, intrauterine growth retardation, and twin gestations, require accurate fetal lung maturity assessment.
  • Amniotic fluid analysis provides a biochemical window into fetal development.

Purpose:

  • To evaluate the efficacy of two biochemical methods, FLM-TDX Abbott and phosphatidylglycerol (PG) determination, for assessing fetal lung maturity.
  • To determine the correlation between these biochemical markers and the risk of hyaline membrane disease (HMD).

Summary:

  • 166 amniotic fluid samples were analyzed using FLM-TDX Abbott and PG tests.
  • Fetal lung maturity was defined as a phospholipid rate >50 mg/g albumin (FLM-TDX Abbott), with or without PG presence.

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  • PG was detected only after 35 weeks of gestation.
  • Significant variability in FLM-TDX values was observed across different gestational ages.
  • In a subset of 30 neonates, FLM-TDX values <30 were associated with HMD, while a value of 52 was observed in one HMD case.

    • Impact:

    • The FLM-TDX Abbott test is confirmed as a reliable tool for assessing fetal lung maturity.
    • The test's utility is independent of gestational age, offering a valuable diagnostic aid.
    • Accurate fetal lung maturity assessment can guide clinical decisions and potentially reduce the incidence of HMD.