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Brain banking for immunocytochemistry and autoradiography
C Eymin1, D Jordan, G Saint-Pierre
1Laboratoire d'Anatomie Pathologique, Faculté de Médecine Alexis Carrel, Lyon, France.
Journal of Neural Transmission. Supplementum
|January 1, 1993
Summary
Human brain banks collect matched normal and pathological brains from autopsies for studying nervous system diseases. Well-documented patients and precise dissection ensure high-quality tissue for research, including histology and biochemistry.
Area of Science:
- Neuroscience
- Pathology
- Biochemistry
Background:
- Human brain banks are crucial for studying neurological diseases.
- High-quality tissue requires precise autopsy and documentation.
Purpose of the Study:
- To outline the establishment and utility of human brain banks.
- To discuss brain banking in relation to various research methodologies.
Main Methods:
- Autopsy with short post-mortem delay.
- Collection of clinically and neuropathologically documented patient data.
- Storage of brain tissue as fixed or frozen samples.
Main Results:
- Brain dissection follows precise anatomical boundaries.
- Tissue is processed for histological, immunocytochemical, biochemical, and autoradiographic studies.
- Acknowledges interindividual variability in human brains.
Conclusions:
- Well-documented human brain banks are essential for large-scale investigations.
- Standardized protocols ensure tissue integrity for diverse research applications.
- Addressing neuroanatomical data gaps is vital for comparative studies.