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X-irradiation-induced emesis in Suncus murinus
1Department of Chemical Pharmacology Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Journal of Radiation Research
|June 1, 1993
Summary
X-irradiation causes vomiting in Suncus murinus, with abdominal exposure being most effective. Serotonin 5-HT3 receptor antagonists and vagotomy can prevent this radiation-induced emesis.
Area of Science:
- Radiation biology
- Neuroscience
- Pharmacology
Background:
- X-irradiation can induce emesis (vomiting).
- Understanding the mechanisms and effective treatments for radiation-induced emesis is crucial for patient care during radiotherapy and radiation exposure.
- Suncus murinus (house musk shrew) serves as a model organism.
Purpose of the Study:
- To investigate X-irradiation-induced emesis in Suncus murinus.
- To determine the effective dose and body regions for X-irradiation-induced emesis.
- To evaluate prophylactic methods against radiation-induced emesis.
Main Methods:
- Whole body and localized X-irradiation were administered to Suncus murinus.
- The ED50 for X-irradiation-induced emesis was calculated.
- Surgical vagotomy and administration of tropisetron (a 5-HT3 receptor antagonist) were used to test prophylactic effects.
Main Results:
- Whole body X-irradiation induced emesis with an ED50 of 429 cGy.
- Abdominal X-irradiation was more effective in inducing emesis than cranial irradiation.
- Surgical vagotomy completely inhibited emesis, and tropisetron prevented emesis with an ID50 of 29 µg/kg.
Conclusions:
- Suncus murinus is a suitable model for studying radiation-induced emesis and developing anti-emetic drugs.
- Serotonin, specifically via 5-HT3 receptors, plays a significant role in X-irradiation-induced emesis.
- The emetic response to X-irradiation in Suncus murinus closely resembles that induced by chemotherapy agents.