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[Dynamic changes in polymorphonuclear cell elastase-alpha 1 protease inhibitor complex, a stress marker, in various
T Ishizaki1, T Ohnishi, T Sakai
13rd Department of Internal Medicine, Fukui Medical School.
Rinsho Byori. the Japanese Journal of Clinical Pathology
|February 1, 1993
Summary
Polymorphonuclear cell elastase-alpha 1 protease inhibitor complex indicates lung damage in pulmonary disorders. Elevated levels in acute respiratory failure suggest it may be a useful prognostic marker.
Area of Science:
- Biochemistry
- Pulmonary Medicine
- Inflammation Research
Context:
- Polymorphonuclear cell elastase-alpha 1 protease inhibitor complex (PMN elastase-alpha 1 PI complex) is elevated in peripheral venous blood during inflammatory diseases.
- Transpulmonary differences in PMN elastase-alpha 1 PI complex levels are observed in patients with pulmonary disorders.
Purpose:
- To investigate the intrapulmonary production of PMN elastase-alpha 1 PI complex.
- To assess the potential of PMN elastase-alpha 1 PI complex as a prognostic marker in acute respiratory failure.
Summary:
- A significant transpulmonary difference (mixed venous blood < arterial blood) of PMN elastase-alpha 1 PI complex was found in patients with pulmonary disorders, but not in those with nonpulmonary disorders.
- Higher arterial than peripheral venous blood levels of PMN elastase-alpha 1 PI complex suggest intrapulmonary production.
- Elevated and sustained levels in acute respiratory failure, even with intensive treatment, indicate PMN elastase may serve as a prognostic marker.
Impact:
- This study suggests intrapulmonary production of PMN elastase-alpha 1 PI complex, potentially indicating lung damage.
- The findings highlight the potential utility of PMN elastase-alpha 1 PI complex as a prognostic indicator in critical respiratory conditions.