[Immunohistopathological analysis of estrogen receptors in human meningioma]

We studied immunohistochemically estrogen receptors (ER) in 25 meningiomas removed from 20 patients using formalin-paraffin sections. Estrogen and progesterone receptors were studies in three case of meningiomas using frozen sections, also. Only two cases show positive reactions for estrogen receptor using formalin-paraffin sections. No correlation was found between estrogen receptor state and histological type, or biological behavior except for sex. Frozen sections failed to show the positive reaction for estrogen or progesterone receptors at all. The data suggest that estrogen receptors are detected in a few of the case with meningioma. Immunohistochemical analysis for estrogen receptor do not offer the useful informations in histopathological diagnosis or estimation of biological behaviors for meningioma on routine laboratory works.