Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pathogenesis of glomerulonephritis

W G Couser1

  • 1Department of Medicine, University of Washington School of Medicine, Seattle.

Kidney International. Supplement
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Immune glomerular injury in glomerulonephritis involves non-inflammatory antibody-mediated damage and inflammatory cell infiltration. Understanding these mechanisms is key to developing treatments for kidney diseases like glomerulosclerosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

World kidney day 2011: protect your kidneys, save your heart.

International journal of organ transplantation medicine·2014
Same author

World Kidney Day 2011: protect your kidneys, save your heart.

Internal medicine journal·2012
Same author

Meeting report on the Bellagio Conference 'prevention of vascular diseases in the emerging world: An approach to global health equity'.

Kidney international·2006
Same author

Endothelial chylomicron binding is altered by interaction with high-density lipoprotein in Heymann's nephritis.

American journal of kidney diseases : the official journal of the National Kidney Foundation·2001
Same author

Intravenous immunoglobulin protects against experimental thrombotic microangiopathy.

Kidney international·2001
Same author

Complement (C5b-9) induces DNA synthesis in rat mesangial cells in vitro.

Kidney international·2001

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Glomerulonephritis involves complex immune-mediated glomerular injury.
  • Mechanisms range from non-inflammatory antibody effects to inflammatory cell involvement.

Purpose of the Study:

  • To review the current understanding of immune glomerular injury mechanisms in glomerulonephritis.
  • To elucidate the roles of antibodies, complement, and inflammatory cells in kidney damage.

Main Methods:

  • Review of existing literature on glomerulonephritis pathogenesis.
  • Analysis of cellular and molecular mechanisms underlying glomerular injury.

Main Results:

  • Non-inflammatory injury: antibodies to glomerular epithelial cell (GEC) antigens or complement C5b-9 complex.

Related Experiment Videos

  • Inflammatory injury: mediated by neutrophils, platelets, macrophages, and mesangial cells.
  • Mesangial cell proliferation involves complement, platelets, and autocrine PDGF signaling, preceding matrix changes.

    • Conclusions:

    • Immune mechanisms in glomerulonephritis are diverse, involving direct antibody effects and inflammatory cell cascades.
    • Understanding these pathways, including mesangial cell proliferation, is crucial for glomerulosclerosis pathogenesis.
    • Further research into GEC activation and mediator release is warranted.