[Correlation between glycemia control and lipid metabolism parameters in children with diabetes mellitus]

Screening for hypercholesterolaemia and hypertriglyceridaemia should be considered in children with diabetes mellitus. Studies on different serum lipids in children with Type I diabetes have shown different results. Hyperglycaemia is the primary abnormality of diabetes. It is logical to consider elevated blood glucose as a possible risk factor in the development of macrovascular disease. Although associations between hyperglycaemia and diabetic complications have been repeatedly shown for microvascular disease, such an association is weaker for macrovascular disease. We report on the results of estimations of different serum lipids in 78 children with diabetes mellitus. These results are compared with those of assessment of the quality of glycaemic control. The results show an association between the quality of glycaemic control and the height of triglycerid concentrations. There were no associations between the quality of glycaemic control and LDL- and HDL-cholesterol. Cholesterol showed only a weak association to glycaemic control. In nearly all patients HDL-cholesterol was estimated to be in the upper normal range. The results are discussed in respect of possible risks for the development of macrovascular disease.