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Early experience with sequential bilateral lung transplantation

M Grimm1, W Wisser, A End

  • 1Second Department of Surgery, University of Vienna, Austria.

The Journal of Thoracic and Cardiovascular Surgery
|September 1, 1993
PubMed
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This study on sequential bilateral lung transplantation showed low perioperative mortality and 70% one-year survival. Survivors demonstrated improved pulmonary function and effective management of graft rejection, preventing obliterative bronchiolitis.

Area of Science:

  • Cardiology
  • Pulmonary Medicine
  • Transplantation Surgery

Background:

  • Sequential bilateral lung transplantation is a complex procedure for end-stage lung disease.
  • Optimizing outcomes and managing complications are critical for patient survival.

Purpose of the Study:

  • To evaluate the outcomes of sequential bilateral lung transplantation.
  • To assess perioperative mortality, long-term survival, and complication rates.

Main Methods:

  • 20 sequential bilateral lung transplantations were performed in 19 patients between April 1990 and May 1992.
  • Data collected included perioperative mortality, survival rates, pulmonary function, and complications such as bronchial dehiscence and stenosis.

Main Results:

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  • Low perioperative mortality (2 patients) was observed.
  • One-year actuarial survival was 70%.
  • Survivors exhibited normal blood oxygen tension and improving pulmonary function, with no instances of bronchial dehiscence. Bronchial stenosis was managed with stents in 7 patients. Aggressive rejection treatment prevented obliterative bronchiolitis.

Conclusions:

  • Sequential bilateral lung transplantation can achieve favorable survival and functional outcomes.
  • Effective management of graft rejection is crucial for preventing long-term complications like obliterative bronchiolitis.