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[Ofloxacin treatment of salmonella infections]

S Unlü1, D Arman, G Altay

  • 1Ankara Universitesi, Tip Fakültesi Klinik Bakteriyoloji ve Enfeksiyon Hastaliklari Anabilim Dali.

Mikrobiyoloji Bulteni
|July 1, 1993
PubMed

Insights

Ofloxacin effectively treated adult salmonella infections, including typhoid and paratyphoid fevers, with rapid fever reduction and no relapses. This study supports ofloxacin as a reliable antibiotic therapy for salmonella in adults.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Context:

  • Salmonella infections pose a significant public health challenge globally.
  • Antibiotic resistance in Salmonella necessitates evaluating effective treatment options.
  • Adult patients present diverse clinical manifestations of Salmonella.

Purpose:

  • To evaluate the efficacy of ofloxacin in treating various adult Salmonella infections.
  • To determine optimal treatment durations for different Salmonella infection types.
  • To assess the safety and outcomes of ofloxacin therapy in a cohort of adult patients.

Summary:

  • 33 adult patients with Salmonella infections (typhoid fever, paratyphoid fever, enterocolitis, gastroenteritis, carriers) were treated with ofloxacin.
  • Treatment durations varied by infection type, ranging from 3 to 10 days.
  • All patients recovered without complications; fever resolved within a mean of 3.0 days. Two carriers cleared Salmonella after 7 days; one severe bacteremia case persisted for 6 months. No relapses occurred.

Impact:

  • Ofloxacin demonstrates high efficacy and safety for treating adult Salmonella infections.
  • The study provides evidence-based recommendations for antibiotic therapy duration.
  • Results contribute to managing Salmonella infections and combating antimicrobial resistance.

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