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Related Experiment Videos

Globulomaxillary cyst revisited

N J D'Silva1, L Anderson

  • 1Department of Oral Biology, University of Washington, Seattle.

Oral Surgery, Oral Medicine, and Oral Pathology
|August 1, 1993
PubMed
Summary
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The globulomaxillary cyst, once dismissed, is re-established as a distinct entity. Recent embryologic findings support its development from entrapped epithelium during facial fusion, validating its clinicopathologic significance.

Area of Science:

  • Oral and Maxillofacial Surgery
  • Developmental Biology
  • Pathology

Background:

  • The globulomaxillary cyst was historically considered a developmental cyst originating from entrapped non-odontogenic epithelium.
  • Its existence was disputed based on theories of facial development that excluded the fusion of facial processes.
  • Previous embryologic models suggested anterior maxilla development through merging growth centers, ruling out ectodermal entrapment.

Purpose of the Study:

  • To review the embryologic and histopathologic evidence regarding the globulomaxillary cyst.
  • To re-evaluate the clinicopathologic status of the globulomaxillary cyst in light of current scientific understanding.

Main Methods:

  • Review of historical and recent embryologic studies on facial development.

Related Experiment Videos

  • Analysis of histopathologic data related to the globulomaxillary cyst.
  • Synthesis of evidence to support or refute the cyst's existence and origin.

    • Main Results:

    • Recent embryologic research contradicts earlier theories, confirming that facial processes do fuse.
    • Epithelium is indeed entrapped in the region between the maxillary lateral incisors and canines during fusion.
    • This entrapment provides a viable embryologic basis for the globulomaxillary cyst.

    Conclusions:

    • The globulomaxillary cyst should be reconsidered as an identifiable clinicopathologic entity.
    • Embryologic evidence now supports the original concept of the globulomaxillary cyst's origin.
    • Histopathologic findings align with the re-established understanding of facial development and epithelial entrapment.