Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Can garlic lower blood pressure? A pilot study

F G McMahon¹, R Vargas

¹Clinical Research Center, New Orleans, LA 70112.

Pharmacotherapy

|July 1, 1993

Summary

A high dose of a popular garlic preparation significantly reduced blood pressure in patients with severe hypertension. This natural remedy showed potential, but further placebo-controlled studies are recommended for broader application.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Distribution and bioconcentration of semivolatile organic compounds (SVOCs) in soils and vascular plant Colobanthus quitensis from Sub-Antarctic and Antarctic regions.

The Science of the total environment·2025

Same author

Can natural zeolite improve the removal of micropollutants in a nitrifying sequencing batch reactor? Insights on bioreactor performance, kinetics, and microbial community using Ibuprofen and Diclofenac as model micropollutants.

Chemosphere·2024

Same author

Preeclampsia and risk of maternal pulmonary hypertension at high altitude in Bolivia.

Journal of developmental origins of health and disease·2023

Same author

Occurrence, source estimation, and risk assessment of Polycyclic Aromatic Hydrocarbons in coastal seawaters from the Quintero Industrial Complex (Valparaíso, Chile).

The Science of the total environment·2023

Same author

Biogeosciences Perspectives on Integrated, Coordinated, Open, Networked (ICON) Science.

Earth and space science (Hoboken, N.J.)·2022

Same author

Composite design bioinspired by the mesocarp of Brazil nut (<i>Bertholletia excelsa</i>).

Bioinspiration & biomimetics·2022

Area of Science:

Cardiovascular Research
Nutritional Science
Herbal Medicine Efficacy

Background:

Hypertension is a widespread cardiovascular condition requiring effective management strategies.
Garlic preparations are explored for their potential antihypertensive properties.
Allicin is a key bioactive compound in garlic linked to health benefits.

Purpose of the Study:

To evaluate the effect of a specific garlic preparation on blood pressure in patients with severe hypertension.
To assess the safety and efficacy of a high-dose garlic supplement.

Main Methods:

An open-label study involving nine patients diagnosed with severe hypertension (diastolic blood pressure ≥ 115 mm Hg).
Administration of a popular garlic preparation containing 1.3% allicin at a large dose (2400 mg).
Monitoring of sitting blood pressure at various time points post-administration.

Main Results:

A reduction in blood pressure was observed, with a peak effect approximately 5 hours after dosing.
Sitting blood pressure decreased by 7/16 mm Hg (+/- 3/2 SD).
A statistically significant decrease in diastolic blood pressure (p < 0.05) was noted between 5 and 14 hours post-dose, with no significant side effects reported.

Conclusions:

The studied garlic preparation demonstrated a blood pressure-lowering effect in patients with severe hypertension.
Further placebo-controlled, double-blind studies are warranted to confirm these findings.
Future research should investigate conventional doses in patients with mild to moderate hypertension.

Related Experiment Videos