[Risk of alloimmunization in the granulocyte concentrate recipient]

Forty five patients with diffused peritonitis, complicated with septic shock and neutropenia, have been analysed. Granulocyte concentrate has been administered to 25 patients with negative results of tests detecting lymphocytotoxic and leuko-agglutinin antibodies. Such antibodies have been detected in 35.5% of all patients. These patients have not received granulocyte concentrate. During a 20-day follow up period, antibodies have been produced in 20% of granulocyte concentrate recipients. No signs of alloimmunisation have been noted in 49% of patients with severe peritonitis during the whole follow up period. Non-hemolytic symptoms after transfusions have been seen in 40% of granulocyte recipients and accompanied 16% of all transfusions. No correlation with the symptoms of alloimmunisation was noted.