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Cerebral circulation during diabetes mellitus

W G Mayhan1

  • 1Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha 68198-4575.

Pharmacology & Therapeutics
|February 1, 1993
PubMed
Summary

Diabetes mellitus causes hyperglycemia and vascular damage. This review examines how diabetes mellitus specifically impacts the brain's blood vessels, detailing structural and functional changes.

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Area of Science:

  • Endocrinology
  • Neurology
  • Vascular Biology

Background:

  • Diabetes mellitus is a metabolic disorder defined by hyperglycemia and insulin deficiency.
  • Hyperglycemia drives macro- and microvascular pathology in diabetes.
  • Diabetes significantly affects the peripheral circulation, but cerebral impacts are also critical.

Purpose of the Study:

  • To review the morphological and functional alterations in the cerebral circulation associated with diabetes mellitus.
  • To highlight the importance of understanding diabetes-related cerebrovascular changes.

Main Methods:

  • Literature review focusing on studies examining the cerebral circulation in diabetes mellitus.
  • Analysis of morphological changes in cerebral blood vessels.
  • Evaluation of functional alterations in the brain's vascular system due to diabetes.

Main Results:

  • Hyperglycemia is a key factor in diabetes-induced vascular changes.
  • Diabetes mellitus leads to both structural and functional modifications in cerebral blood vessels.
  • The review synthesizes current knowledge on diabetes' effects on the brain's vasculature.

Conclusions:

  • Diabetes mellitus profoundly impacts the cerebral circulation.
  • Understanding these cerebrovascular alterations is crucial for managing diabetes complications.
  • Further research into diabetes-related brain vascular changes is warranted.

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