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[Infection and diabetes]

H Gin1

  • 1Clinique Médicale, Hôpital Pellegrin, Bordeaux.

La Revue De Medecine Interne
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Diabetic patients face higher risks of bacterial infections due to impaired immune cell function, necessitating tailored antibiotic strategies. Viral and fungal infections in diabetics are less understood, with immune responses often remaining intact.

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Area of Science:

  • Infectious Diseases
  • Endocrinology
  • Immunology

Background:

  • Diabetic patients exhibit increased susceptibility to infections.
  • A distinction exists between bacterial and viral infection risks in diabetes.
  • Bacterial infections, such as septicemia, are more prevalent in individuals with diabetes.

Purpose of the Study:

  • To explore the differential susceptibility of diabetic patients to bacterial, viral, and fungal infections.
  • To elucidate the mechanisms underlying increased bacterial infection risk in diabetes.
  • To assess the impact of glycemic control on infection management and antibiotic efficacy.

Main Methods:

  • Review of existing literature on diabetes and infection susceptibility.
  • Analysis of the influence of hyperglycemia on polymorphonuclear cell function.

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  • Examination of specific clinical entities like urinary tract infections and diabetic foot.

    • Main Results:

    • Hyperglycemia impairs polymorphonuclear cell function, increasing bacterial infection risk.
    • Specific diabetic infections like UTIs and diabetic foot may require modified antibiotic therapies.
    • Antibiotic pharmacokinetics are generally not altered by hyperglycemia, but normoglycemia is crucial for effective treatment.
    • Cellular and humoral immune responses to viral infections are typically not altered in diabetic patients, barring autoimmune conditions.

    Conclusions:

    • Diabetic patients require specific management strategies for bacterial infections, focusing on glycemic control and potentially adjusted antibiotic regimens.
    • While bacterial infections pose a significant threat, viral infections may not be as profoundly affected in the diabetic population.
    • Further research into mycological infections in diabetics is warranted.