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Nasal hyperreactivity. A histamine provocation model

M Ohm1, J E Juto

  • 1Department of Otorhinolaryngology, Södersjukhuset, Stockholm, Sweden.

Rhinology
|June 1, 1993
PubMed
Summary
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Non-allergic individuals with nasal hyperreactivity show distinct responses to histamine challenges. This study found no evidence of a priming effect in these non-allergic rhinitis patients.

Area of Science:

  • Otolaryngology
  • Allergy and Immunology
  • Physiology

Background:

  • Perennial rhinitis affects many individuals, presenting with nasal symptoms like swelling or discharge.
  • Allergic investigations often exclude a significant portion of rhinitis patients, suggesting non-allergic causes.
  • Nasal hyperreactivity is a key feature in some non-allergic rhinitis cases.

Purpose of the Study:

  • To determine if histamine standardization tests can differentiate non-allergic individuals with nasal hyperreactivity from healthy controls.
  • To investigate the potential presence of a priming effect in non-allergic rhinitis.

Main Methods:

  • Seven patients with perennial rhinitis and negative allergy tests underwent repeated histamine challenges.
  • Rhinostereometry was employed to measure nasal mucosal reactions to increasing histamine concentrations.

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  • A control group of healthy volunteers was included for comparison.

    • Main Results:

    • A statistically significant difference in histamine response was observed between the non-allergic rhinitis group and healthy controls.
    • No evidence of a priming effect (increased sensitivity upon repeated provocation) was detected in the study group.

    Conclusions:

    • Histamine standardization tests can help identify non-allergic individuals with nasal hyperreactivity.
    • The findings do not support the presence of a priming effect in this specific non-allergic rhinitis cohort.