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Ovarian cortex surrounding benign neoplasms: a histologic study

F Maneschi1, L Marasá, S Incandela

  • 1Department of Obstetrics and Gynecology, 2nd University of Rome, Italy.

American Journal of Obstetrics and Gynecology
|August 1, 1993
PubMed
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The ovarian cortex surrounding benign teratomas and cystadenomas shows normal morphology and vascularity. Endometriomas, however, are linked to stromal changes and reduced follicular activity in the adjacent ovarian cortex.

Area of Science:

  • Reproductive biology
  • Gynecologic pathology
  • Ovarian cyst research

Background:

  • Benign ovarian cysts are common gynecologic conditions.
  • Understanding the impact of these cysts on surrounding ovarian tissue is crucial for diagnosis and management.
  • Ovarian cortex morphology and vascularity can be affected by intraparenchymal lesions.

Purpose of the Study:

  • To evaluate the functional morphologic characteristics of the ovarian cortex adjacent to benign ovarian cysts.
  • To compare the effects of mature teratomas, benign cystadenomas, and endometriomas on the surrounding ovarian cortex.

Main Methods:

  • Histopathologic examination of 54 ovarian specimens from 48 patients with benign cysts (teratomas, cystadenomas, endometriomas).
  • Assessment of follicular density and stromal alterations using semiquantitative scales.

Related Experiment Videos

  • Evaluation of the cortical vascular network using anti-endothelial cell antibodies (anti-VW, QBEND/10).
  • Statistical analysis using chi-squared and Mann-Whitney U tests.

    • Main Results:

    • Ovarian cortex surrounding teratomas (92%) and cystadenomas (77%) largely retained normal morphologic patterns and vascularity (84% and 78%, respectively).
    • In contrast, ovarian cortex adjacent to endometriomas showed altered morphology (19%) and vascularity (22%) in a significant proportion of cases.
    • Microscopic endometriosis was found in the stroma of 82% of endometrioma specimens; stromal alterations related to teratomas and cystadenomas were absent.

    Conclusions:

    • The ovarian cortex stretched by teratomas or cystadenomas remains morphologically unaltered.
    • Endometriomas are associated with microscopic stromal implants and exhibit reduced follicular number and activity in the adjacent ovarian cortex.
    • These findings highlight differential impacts of benign ovarian cyst types on the surrounding ovarian cortex.