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[Severe bone malformations in fetal valproic acid disease]
G Lorenzo Sanz1, C Serna Saugar, A Quintana Castilla
1Sección de Neuropediatría, Hospital Ramón y Cajal, Madrid.
Anales Espanoles De Pediatria
|July 1, 1993
Summary
Valproic acid exposure during pregnancy may cause severe birth defects. This case report highlights skeletal malformations and other congenital anomalies in an infant exposed to valproic acid, supporting its teratogenic potential.
Area of Science:
- Teratology
- Developmental Biology
- Clinical Case Reports
Background:
- Valproic acid is a widely used antiepileptic and mood-stabilizing drug.
- Previous reports suggest potential dysmorphogenic and teratogenic effects of valproic acid in pregnant women.