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[Neonatal conjunctivitis: microbiologic study and antibiotic sensitivity]

M T Martínez Ruiz1, F J Ascaso Puyuelo, J Navales Bertol

  • 1Departamento de Oftalmología, Hospital Clínico Universitario, Zaragoza.

Anales Espanoles De Pediatria
|July 1, 1993
PubMed
Summary

Bacterial conjunctivitis is common in newborns. Most bacteria causing infant conjunctivitis are sensitive to common antibiotics, but resistant to penicillin. Cefotaxime, ceftriaxone, and ciprofloxacin show high activity.

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Area of Science:

  • Ophthalmology
  • Microbiology
  • Neonatal Care

Context:

  • Conjunctivitis is a frequent ocular infection in neonates.
  • Bacterial pathogens are a significant cause of neonatal conjunctivitis.
  • Retrospective analysis of conjunctival samples from infants.

Purpose:

  • To identify common bacterial pathogens causing conjunctivitis in infants.
  • To determine the antibiotic sensitivity patterns of isolated bacteria.
  • To evaluate the efficacy of available ophthalmic preparations.

Summary:

  • 84% of conjunctival samples from infants with conjunctivitis yielded positive bacterial cultures.
  • Staphylococcus epidermidis, Staphylococcus aureus, and Streptococcus pneumoniae were the most frequent isolates.

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  • Bacteria showed high sensitivity to most tested antibiotics, except penicillin, with cefotaxime, ceftriaxone, and ciprofloxacin demonstrating superior in vitro activity.

    • Impact:

    • Informs clinical decisions for treating bacterial conjunctivitis in neonates.
    • Highlights the ineffectiveness of penicillin-based treatments.
    • Identifies effective antibiotic agents for ophthalmic preparations, including sulfonamides, chloramphenicol, rifampicin, erythromycin, and tobramycin.